Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy

Title: Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy

Volume: 6 Issue: 6

Author(s): Camilla Tincati, Dario Bauer, Giusi M. Bellistri, Maddalena Casana, Roberto Ranieri, Teresa Bini, Giulia Marchetti and Antonella Arminio Monforte

Affiliation:

Keywords: Atherosclerosis, cardiovascular risk, HAART, immune activation, intima media thickness

Abstract: We describe the case of a young HIV-positive man on effective HAART with excellent viro-immunological control who presented a massive cardiac infarction. Despite the presence of clinical risk factors for cardiovascular disease, the patient had normal arterial carotid IMT values, known to be strong predictors of atherosclerosis and stroke. Interestingly, parameters of T-cell activation (CD8+CD38+) were shown to increase just before the onset of myocardial infarction. As T-cell activation is known to mediate atherosclerosis, the authors suggest that surrogate immunologic markers should be identified to better assess cardiovascular risk in the setting of HIV infection.

Cite this article as:

Tincati Camilla, Bauer Dario, Bellistri M. Giusi, Casana Maddalena, Ranieri Roberto, Bini Teresa, Marchetti Giulia and Monforte Arminio Antonella, Sudden Cardiac Death in a Young HIV-Positive Man on Effective Antiretroviral Therapy, Current HIV Research 2008; 6 (6) . https://dx.doi.org/10.2174/157016208786501517