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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Chemokine Receptors Expression on T Cells and Response to HAART Among Chronic HIV-1-Infected Subjects

Author(s): Adriana Brito, Paula O. Rigato, Alexandre Almeida, Simone S. Fernandes, Claudio R. Gonsalez, Luiz A.M. Fonseca, Alberto J.S. Duarte and Jorge Casseb

Volume 6, Issue 6, 2008

Page: [539 - 543] Pages: 5

DOI: 10.2174/157016208786501436

Price: $65


Chemokines receptors are used by HIV-1 for entry into CD4+ T cells. The β-chemokines are capable of inhibiting HIV replication. This study determined the CCR5 and CXCR4 expression on T cells in HIV-1-infected patients treated with HAART. The successfully treated group (plasma viral load < 400 copies/mL), when compared with the failure group (plasma viral load > 400 copies/mL), had higher median CD4+ T cells count (583 and 245 cells/mm3; respectively, p < 0.0001). The failure patients had higher numbers and intensity of CCR5 and CXCR4-expressing T cells. Successfully treated patients were able to normalize the co-receptors expression-over on T cells. The viremic group showed higher CCR5 expression on CD4+ T cells and lower number of cells; CCR5 expression was normalized in the aviremic group; the naive group showed lower CCR5 expression and higher numbers of CD4 T cells; all groups showed normal CXCR4 expression compared to healthy controls. These findings may have clinical implications, since down-regulation of these co-receptors could be an adjuvant strategy for anti-HIV treatment.

Keywords: HIV-1, chemokines, co-receptors, CCR5, CXCR4, antiretroviral therapy

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