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Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Current Topics of Organic and Biological Chemistry of Annonaceous Acetogenins and their Synthetic Mimics

Author(s): Hidefumi Makabe, Hiroyuki Konno and Hideto Miyoshi

Volume 5, Issue 3, 2008

Page: [213 - 229] Pages: 17

DOI: 10.2174/157016308785739820

Price: $65

Abstract

Annonaceous acetogenins are a large family of natural polyketides. So far, more than 430 compounds have been isolated. Biologically, they are among the most potent of the known inhibitors of complex I (NADH-ubiquinone oxidoreductase) in mitochondrial electron transfer system. Herein, we would like to conduct an overview on the progress of the total synthesis, structural revisions, structure activity relationship for the inhibition of complex I, and action mechanism.

Keywords: Annonaceous acetogenin, total synthesis, mitochondrial complex I, antitumor


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