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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Interactions of β - and Hydroxypropyl-β-Cyclodextrin with Some Purine Alkaloids:Thermodynamic Study

Author(s): Irina V. Terekhova

Volume 5, Issue 2, 2008

Page: [168 - 172] Pages: 5

DOI: 10.2174/157016308784746201

Price: $65


The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between β-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that β-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both β-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and β-cyclodextrin on the thermodynamic parameters of interaction was discussed.

Keywords: Cyclodextrin, xanthines, solubility, calorimetry, thermodynamics of interactions

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