Abstract
The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between β-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that β-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both β-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and β-cyclodextrin on the thermodynamic parameters of interaction was discussed.
Keywords: Cyclodextrin, xanthines, solubility, calorimetry, thermodynamics of interactions
Current Drug Discovery Technologies
Title: Interactions of β - and Hydroxypropyl-β-Cyclodextrin with Some Purine Alkaloids:Thermodynamic Study
Volume: 5 Issue: 2
Author(s): Irina V. Terekhova
Affiliation:
Keywords: Cyclodextrin, xanthines, solubility, calorimetry, thermodynamics of interactions
Abstract: The effect of native and hydroxypropylated β-cyclodextrin on the solubility and activity of some purine alkaloids was examined. For this purpose, the solubility of purine alkaloids in pure water and in aqueous solutions of mentioned β-cyclodextrins was determined at 298.15 K. Stability constants of inclusion complexes and their stoichiometry were obtained from solubility diagrams. Enthalpic characteristics of interactions occurring between β-cyclodextrins and purine alkaloids in aqueous solution were calculated from the direct calorimetric measurements. It was found, that β-cyclodextrin forms with purine alkaloids weak complexes which are stabilized only by the entropy term. Due to very low complexing affinity of both β-cyclodextrins to studied purine alkaloids their solubilizing effect is insignificant. The influence of structure of purine alkaloids and β-cyclodextrin on the thermodynamic parameters of interaction was discussed.
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Cite this article as:
Terekhova V. Irina, Interactions of β - and Hydroxypropyl-β-Cyclodextrin with Some Purine Alkaloids:Thermodynamic Study, Current Drug Discovery Technologies 2008; 5 (2) . https://dx.doi.org/10.2174/157016308784746201
DOI https://dx.doi.org/10.2174/157016308784746201 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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