Abstract
Protein-protein interactions play a crucial role in numerous vital cell functions. However proteinprotein interactions are also responsible for pathological formation of protein aggregates, which determine the development of several diseases. The key role of protein-protein interactions for manifestation of numerous cell functions attracts much attention to protein complexes as perspective drug targets. So design or discovery of small molecules that would regulate protein-protein interactions represents great pharmacological interest. The recent progress in understanding of mechanism protein-protein interaction, including role of flexibility of protein-protein interfaces, thermodynamic of complex formation, discovery of small molecules modifying protein-protein interactions, the advantages and limitation of protein-protein inhibitors as potential drugs are discussed in this review.
Keywords: Protein-protein interaction, inhibitors, target, dimerization, drug, flexibility, allosteric inhibition
Current Computer-Aided Drug Design
Title: Inhibitors of Protein-Protein Interactions as Potential Drugs
Volume: 3 Issue: 1
Author(s): Alexander V. Veselovsky and Alexander I. Archakov
Affiliation:
Keywords: Protein-protein interaction, inhibitors, target, dimerization, drug, flexibility, allosteric inhibition
Abstract: Protein-protein interactions play a crucial role in numerous vital cell functions. However proteinprotein interactions are also responsible for pathological formation of protein aggregates, which determine the development of several diseases. The key role of protein-protein interactions for manifestation of numerous cell functions attracts much attention to protein complexes as perspective drug targets. So design or discovery of small molecules that would regulate protein-protein interactions represents great pharmacological interest. The recent progress in understanding of mechanism protein-protein interaction, including role of flexibility of protein-protein interfaces, thermodynamic of complex formation, discovery of small molecules modifying protein-protein interactions, the advantages and limitation of protein-protein inhibitors as potential drugs are discussed in this review.
Export Options
About this article
Cite this article as:
Veselovsky V. Alexander and Archakov I. Alexander, Inhibitors of Protein-Protein Interactions as Potential Drugs, Current Computer-Aided Drug Design 2007; 3 (1) . https://dx.doi.org/10.2174/157340907780058754
DOI https://dx.doi.org/10.2174/157340907780058754 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
Current Clinical Pharmacology Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research Noradrenergic System in Down Syndrome and Alzheimer’s Disease A Target for Therapy
Current Alzheimer Research From Multiple PAR1 Receptor/Protein Interactions to their Multiple Therapeutic Implications
Current Topics in Medicinal Chemistry The Interplay between G-quadruplex and Transcription
Current Medicinal Chemistry Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease
CNS & Neurological Disorders - Drug Targets A New Model for Academics Based Drug Discovery
Current Alzheimer Research Ligands Targeting the Excitatory Amino Acid Transporters (EAATs)
Current Topics in Medicinal Chemistry SS31, a Small Molecule Antioxidant Peptide, Attenuates β-Amyloid Elevation, Mitochondrial/Synaptic Deterioration and Cognitive Deficit in SAMP8 Mice
Current Alzheimer Research Mast Cell – Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications
CNS & Neurological Disorders - Drug Targets Topiramate: Its Pharmacological Properties and Therapeutic Efficacy in Epilepsy
Mini-Reviews in Medicinal Chemistry Does Human Alpha-Synuclein Behave Like Prions?
CNS & Neurological Disorders - Drug Targets Therapeutic Potential of Hepatocyte Growth Factor for Treating Neurological Diseases
Current Drug Therapy Silencing of Disease-related Genes by Small Interfering RNAs
Current Molecular Medicine Group I Metabotropic Glutamate Receptor Signalling and its Implication in Neurological Disease
CNS & Neurological Disorders - Drug Targets Diagnosis, Pathogenesis and Therapeutic Targets in Amyotrophic Lateral Sclerosis
CNS & Neurological Disorders - Drug Targets The Role of Calcium Stores in Apoptosis and Autophagy
Current Molecular Medicine Assessment of Glomerular and Tubular Function
Current Pediatric Reviews Effects of Therapeutic Hypothermia on the Glial Proteome and Phenotype
Current Protein & Peptide Science Intracompartmental Delivery of CNTF as Therapy for Huntingtons Disease and Retinitis Pigmentosa
Current Gene Therapy