Abstract
The development of nanotechnology relies heavily on the ability to observe and probe at molecular scales. Thus, breakthroughs in instrumentation and techniques play a significant role in the advancement in nanoscience. In this article, we survey recent developments in observing, trapping, and probing single molecules in solution. We give particular attention to patents that cover enabling instrumentation in each of these related areas including, respectively, fluorescence imaging, optical tweezers, and anti-Brownian traps. We conclude by highlighting a broad trend in the literature and patent base from observation toward active interrogation of single molecules in solution.
Keywords: Optical trap, fluorescent resonance energy transfer (FRET), optical tweezers, anti-brownian electrokinetic trap, single-molecule spectroscopy, single-molecule trapping, fluorescent tags
Recent Patents on Nanotechnology
Title: Interrogating Single Molecules
Volume: 2 Issue: 1
Author(s): Alexander D. Wissner-Gross and Lin Cong
Affiliation:
Keywords: Optical trap, fluorescent resonance energy transfer (FRET), optical tweezers, anti-brownian electrokinetic trap, single-molecule spectroscopy, single-molecule trapping, fluorescent tags
Abstract: The development of nanotechnology relies heavily on the ability to observe and probe at molecular scales. Thus, breakthroughs in instrumentation and techniques play a significant role in the advancement in nanoscience. In this article, we survey recent developments in observing, trapping, and probing single molecules in solution. We give particular attention to patents that cover enabling instrumentation in each of these related areas including, respectively, fluorescence imaging, optical tweezers, and anti-Brownian traps. We conclude by highlighting a broad trend in the literature and patent base from observation toward active interrogation of single molecules in solution.
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Cite this article as:
Wissner-Gross D. Alexander and Cong Lin, Interrogating Single Molecules, Recent Patents on Nanotechnology 2008; 2 (1) . https://dx.doi.org/10.2174/187221008783478644
DOI https://dx.doi.org/10.2174/187221008783478644 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
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