Human Immunodeficiency Virus Interactions with CD8+ T Lymphocytes

Title: Human Immunodeficiency Virus Interactions with CD8+ T Lymphocytes

Volume: 6 Issue: 1

Author(s): Nitin K. Saksena, Jing Qin Wu, Simon J. Potter, John Wilkinson and Bin Wang

Affiliation:

Keywords: Dendritic Cells, Viremia, CD8 cell antiviral factor, highly active antiretroviral therapy, HIV-1 infection

Abstract: Human immunodeficiency virus (HIV)-specific CD8+ T cells can mediate anti-HIV activity by both cytolytic (cytotoxic T lymphocyte or CTL) and non-cytolytic mechanisms (antiviral) and play a crucial role in HIV pathogenesis. Both mechanisms actively contribute to the control of HIV in vivo. The non-cytolytic CD8+T cells from individuals infected with HIV suppress virus replication in CD4+ T cells in vitro by a non-cytolytic mechanism that involves interplay of several chemokines and an unidentified secreted soluble CD8 (+)-cell antiviral factor (CAF). There is immense value of these two distinct CD8 activities in anti-HIV responses and their necessity to be maintained during highly active antiretroviral therapy (HAART). The aim of this review is to provide an overview of some of the novel aspects of CD8+ T cell interactions with HIV, their role in HIV pathogenesis, HAART therapy, HIV disease progression, gene expression and interactions with other cell types during HIV infection.

Cite this article as:

Saksena K. Nitin, Wu Qin Jing, Potter J. Simon, Wilkinson John and Wang Bin, Human Immunodeficiency Virus Interactions with CD8+ T Lymphocytes, Current HIV Research 2008; 6 (1) . https://dx.doi.org/10.2174/157016208783572008