For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for bioactive agents. Until now several reviews have been compiled on the nanoparticulate system concentrating on the various research works but there is no review, which compiles patents available for the nanoparticulate systems. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. A review on patents related to the nanoparticulate drug delivery systems has been prepared to summarize patents reported for the methods of preparation, applications in therapies and drug delivery. The status of patents for oral, topical and parenteral delivery has been discussed and the commercialized technology of nanoparticles for medical application has also been compiled.