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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Metabolite Interference in Pharmacokinetic Studies

Author(s): Mehran F. Moghaddam, Jui-Hsiang Fan, Yang Tang, Oleg Khatsenko, Jason C. Katz and Michael A. Shirley

Volume 1, Issue 4, 2007

Page: [272 - 275] Pages: 4

DOI: 10.2174/187231207783221475

Price: $65


Our policy of conducting biotransformation studies with extended chromatography prior to pharmacokinetic bioanalyses allowed us to quickly detect an unusual, cis/trans metabolite in rat plasma that was inseparable using a short chromatographic method. We caution investigators that short methods invite unknown isobaric metabolites to cause inaccuracies in plasma concentration measurements.

Keywords: Pharmacokinetics, metabolite, isomer, chromatography, coelution, aminocyclohexanol

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