Abstract
Upon viral exposure, antibodies serve as a first line of defense and can act by preventing infection or reducing the viral burden. The ability of antibodies to confer protection against HIV has been demonstrated by several studies using the passive transfer of neutralizing antibodies in the non-human primate challenge model. Therefore, efforts have been made to induce a similarly protective humoral immune response by vaccination with antigens derived from HIV. Thus far, the results have been disappointing. Humoral immune responses elicited via vaccination display activities that are generally much less potent and broad as compared to those induced during natural infection. However, recently there have been increased efforts to systematically identify and compare the epitopes potentially critical to the generation of protective antibody responses in the hope that this will lead to improved strategies and superior immunogen design. As a critical part of this process, novel methods to monitor protective antibody responses will also need to be vigorously explored and improved, then validated in both preclinical and clinical settings.
Keywords: HIV, antibodies, neutralization, epitopes
Current HIV Research
Title: Broadening Our View of Protective Antibody Responses Against HIV
Volume: 5 Issue: 6
Author(s): Brian Burke and Susan W. Barnett
Affiliation:
Keywords: HIV, antibodies, neutralization, epitopes
Abstract: Upon viral exposure, antibodies serve as a first line of defense and can act by preventing infection or reducing the viral burden. The ability of antibodies to confer protection against HIV has been demonstrated by several studies using the passive transfer of neutralizing antibodies in the non-human primate challenge model. Therefore, efforts have been made to induce a similarly protective humoral immune response by vaccination with antigens derived from HIV. Thus far, the results have been disappointing. Humoral immune responses elicited via vaccination display activities that are generally much less potent and broad as compared to those induced during natural infection. However, recently there have been increased efforts to systematically identify and compare the epitopes potentially critical to the generation of protective antibody responses in the hope that this will lead to improved strategies and superior immunogen design. As a critical part of this process, novel methods to monitor protective antibody responses will also need to be vigorously explored and improved, then validated in both preclinical and clinical settings.
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Cite this article as:
Burke Brian and Barnett W. Susan, Broadening Our View of Protective Antibody Responses Against HIV, Current HIV Research 2007; 5 (6) . https://dx.doi.org/10.2174/157016207782418533
DOI https://dx.doi.org/10.2174/157016207782418533 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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