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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Centralized HIV-1 Envelope Immunogens and Neutralizing Antibodies

Author(s): Feng Gao, Hua-Xin Liao, Beatrice H. Hahn, Norman L. Letvin, Bette T. Korber and Barton F. Haynes

Volume 5, Issue 6, 2007

Page: [572 - 577] Pages: 6

DOI: 10.2174/157016207782418498

Price: $65


Centralized HIV-1 genes (consensus, most recent common ancestor and center of the tree) have recently been explored for induction of broadly reactive immune responses to overcome the extraordinary genetic diversity among HIV- 1 strains. Although all of these strategies are based on artificial sequences predicted by computer programs, they retain biological function, and use the CCR5 co-receptor for entry into target cells as transmitted HIV-1 Envs. Results from laboratory animals indicate that centralized immunogens are superior to many wild-type immunogens for inducing crosssubtype T and B cell immune responses. Structural modifications have improved the ability of consensus Envs to elicit antibody responses that neutralize a spectrum of HIV-1 Env pseudoviruses. However, the more difficult to neutralize tier 2 Env pseudoviruses are generally not neutralized well by anti-consensus Env antibodies, indicating the need for further modifications, new formulations, or additional strategies to generate antibodies that neutralize a full spectrum of transmitted HIV-1 strains.

Keywords: Consensus, ancestor, vaccine, neutralizing antibodies, variation

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