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Current Drug Targets - Immune, Endocrine & Metabolic Disorders


ISSN (Print): 1568-0088
ISSN (Online): 1875-5917

Photomedical Approaches for the Diagnosis and Treatment of Gynecologic Cancers

Author(s): R. Hornung

Volume 1, Issue 2, 2001

Page: [165 - 177] Pages: 13

DOI: 10.2174/1568005310101020165

Price: $65


Malignant tumors of the female reproductive organs have a high incidence and mortality. Despite modern technology, diagnostics and therapeutics have substantial limitations. Detection of autofluorescence, photosensitizer mediated fluorescence, and near-infrared-spectra are new approaches to diagnose gynecologic malignancies and premalignant lesions. Photodynamic therapy (PDT) is currently being evaluated for the treatment of gynecologic cancers and precancers. New porphyrin based photosensitizers promise a selective tumor targeting and consequently a selective treatment of surgically not removable cancers. The present article summarizes the role of photomedicine in diagnostics and treatments of malignant disease of the female genital tract. Interactions between PDT and the immune system are discussed.

Keywords: Gynecologic Cancers, autofluorescence, photosensitizer, mediated tissue necrosis, Photodynamic therapy (PDT), near-infrared-spectra, photodynamic endometrial ablation

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