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Current Drug Targets - Inflammation & Allergy

Editor-in-Chief

ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Chlamydial Heat Shock Protein 60 and Lipopolysaccharide: Potential Virulence Determinants in Atherogenesis

Author(s): Murat V. Kalayoglu

Volume 1 , Issue 3 , 2002

Page: [249 - 255] Pages: 7

DOI: 10.2174/1568010023344652

Price: $65

Abstract

Chlamydia pneumoniae infection is associated with atherosclerosis and may be an emerging risk factor in coronary artery disease. C. pneumoniae can infect, multiply within and modulate the function of all atheroma cell types. Specific chlamydial virulence determinants have been identified that permit interaction with host cells and dysregulate cell function. In particular, chlamydial heat shock protein 60 and lipopolysaccharide may modulate cell function to dysregulate lipid metabolism, induce inflammatory cytokine cascades and trigger production of cross-reactive antibodies that initiate and promote atherogenesis. This paper reviews chlamydial heat shock protein 60 and lipopolysaccharide as potential virulence determinants in atherogenesis.

Keywords: Chlamydial, Protein, Lipopolysaccharide, Atherogenesis, ATHEROSCLEROSIS


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