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Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents


ISSN (Print): 1568-0134
ISSN (Online): 1568-0134

Transcriptional Regulation as a Pharmacologic Intervention

Author(s): Michael R. Briggs

Volume 2, Issue 1, 2002

Page: [1 - 9] Pages: 9

DOI: 10.2174/1568013024606422

Price: $65


Disease phenotype and manifestation can largely be attributed to aberrant patterns of gene expression. This is becoming increasingly evident as genomics and bioinformatics tools provide us with new information on how gene expression patterns change in the pathophysiological state. Transcriptional control mechanisms influence these genetic networks and some success has been attained by manipulating the action of transcription factors toward a more favorable therapeutic profile. From endocrine-mimics that modulate nuclear receptor driven gene expression to indirectly altering homeostatic regulation of lipoprotein metabolism, transcription factor pharmacotherapy is a current reality and will increasingly contribute to the treatment of human disease.

Keywords: transcriptional regulation, selective estrogen receptor modulators(serms), peroxisome proliferator activated receptors-modulators

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