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Current Medicinal Chemistry - Cardiovascular & Hematological Agents


ISSN (Print): 1568-0169
ISSN (Online): 1875-6174

Bone Marrow Reconstitution as a Relevant Model of Genetically Programmed Leukemia

Author(s): A. Dolnikov, S. Shen, T. Passioura and G. Symonds

Volume 1, Issue 2, 2003

Page: [83 - 97] Pages: 15

DOI: 10.2174/1568016033477531

Price: $65


Mouse model systems which allow bone marrow reconstitution can be used to analyse genetically programmed leukemia. The original and most widely used system is that of post 5-fluorouracil mouse hematopoietic stem cells (HSC) into lethally irradiated syngeneic mice. Another more recent system allows analysis of human HSCs in the NODSCID mouse. Both systems are discussed as models for analysis of gene induced leukemia.

Keywords: leukemia, bone marrow reconstitution model, oncogenes, retroviruses, gene transfer

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