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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Rodent Models for HIV-1 Infection and Disease

Author(s): Marc van Maanen and Richard E. Sutton

Volume 1, Issue 1, 2003

Page: [121 - 130] Pages: 10

DOI: 10.2174/1570162033352075


The development of a predictive, small animal model for human immunodeficiency virus type 1 (HIV-1) disease would greatly facilitate the analysis of many aspects of viral infection, pathogenesis and treatment. While numerous small animal models exist which emulate various aspects of HIV-1 infection and / or disease in humans, none of these models support robust HIV-1 replication within the context of an intact immune system. Despite this major limitation, these models have helped to elucidate different aspects of HIV-1 pathogenesis in humans. Moreover, recent advances regarding the underlying nature of the blocks to viral replication in non-human cells have raised the possibility that rodents may be engineered to support HIV-1 infection. This review will focus on recent attempts to develop a rodent model for HIV-1 disease, and will also describe currently available systems for studying HIV-1.

Keywords: mouse, rat, hiv-1 animal model, transgenic, xenograft, aids

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