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Current Medicinal Chemistry - Central Nervous System Agents


ISSN (Print): 1568-0150
ISSN (Online): 1875-6158

Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: Past and Future Roles of 5-HT4 Receptor Agonists

Author(s): Henri Mattes and Hans-Juergen Pfannkuche

Volume 3, Issue 1, 2003

Page: [27 - 36] Pages: 10

DOI: 10.2174/1568015033357724

Price: $65


Understanding the biological consequences of 5-HT4 receptor activation has been a subject of intensive research over the last decade and there is now ample evidence to suggest that activation of these receptors represents a valid approach for the trea tment of f unctional motility disorder s of the gastrointe stina l tra ct. A surve y of 5-HT 4 r ec eptor s, their distribution a nd function, will be pr ovide d. This article will also review 5-HT4 receptor agonists currently on the market, undergoing clinical development, as well as potential new agents that have been discovered.

Keywords: 5-ht4 receptors, 5-ht4 agonist, serotonin agonist

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