Role of CD4 Receptor Down-regulation During HIV-1 Infection

Karine      Levesque; Andres      Finzi; Julie      Binette; Eric   A.   Cohen

doi:10.2174/1570162043485086

Abstract

Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in vivo. This review highlights recent progress made in our understanding of the molecular mechanisms underlying the down-regulation of the CD4 receptor by HIV-1 and describes our current comprehension of the role of CD4 down-regulation during HIV-1 infection.

Keywords: hiv-1, cd4 down-regulation, nef, env, vpu, replication, pathogenesis

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Current HIV Research

Title: Role of CD4 Receptor Down-regulation During HIV-1 Infection

Volume: 2 Issue: 1

Author(s): Karine Levesque, Andres Finzi, Julie Binette and Eric A. Cohen

Affiliation:

Keywords: hiv-1, cd4 down-regulation, nef, env, vpu, replication, pathogenesis

Abstract: Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in vivo. This review highlights recent progress made in our understanding of the molecular mechanisms underlying the down-regulation of the CD4 receptor by HIV-1 and describes our current comprehension of the role of CD4 down-regulation during HIV-1 infection.

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Cite this article as:

Levesque Karine, Finzi Andres, Binette Julie and Cohen A. Eric, Role of CD4 Receptor Down-regulation During HIV-1 Infection, Current HIV Research 2004; 2 (1) . https://dx.doi.org/10.2174/1570162043485086

DOI https://dx.doi.org/10.2174/1570162043485086	Print ISSN 1570-162X
Publisher Name Bentham Science Publisher	Online ISSN 1873-4251

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