Abstract
In a previous work, we have showed in mice infected with an avirulent strain of Toxoplasma gondii and receiving a didanosine treatment, an important decrease of brain cysts. It is why, the purpose of this study was to investigate the effect of didanosine treatment on AIDS patients having developed Toxoplasma encephalitis. 60 patient reports were analyzed: 22 patients (group 1) did not received didanosine in their antiretroviral treatment and 38 (group 2) were treated with didanosine. The results showed that an antiretroviral therapy was prescribed for 93 % of patients, 50 % of them received only zidovudine and protease inhibitors were prescribed for 37 %. The regimens given most frequently were those including zidovudine plus lamivudine or zidovudine plus indinavir. Among the group 1, 18 % have had a relapse of Toxoplasma encephalitis. In the group 2, 37 % of the patients suffered from one episode of TE while 16 % have had two TE after the pause in their didanosine treatment, the maximum occurring between 4 and 24 months after the pause of didanosine. This study showed that didanosine seems to have an effect on cerebral cysts. Also, this work made a synthesis about the different treatment used in AIDS patients and the new molecules yet in development against T. gondii.
Keywords: toxoplasma encephalitis, treatment, didanosine, aids, opportunistic infection
Current HIV Research
Title: Prevalence of Toxoplasma Encephalitis in AIDS Patients Treated with Didanosine Hospitalised in a French Infectious Service
Volume: 2 Issue: 4
Author(s): Marie-Elisabeth Sarciron, Arnaud Gherardi, Chantal Delorme, Dominique Peyramond and Anne-Francoise Petavy
Affiliation:
Keywords: toxoplasma encephalitis, treatment, didanosine, aids, opportunistic infection
Abstract: In a previous work, we have showed in mice infected with an avirulent strain of Toxoplasma gondii and receiving a didanosine treatment, an important decrease of brain cysts. It is why, the purpose of this study was to investigate the effect of didanosine treatment on AIDS patients having developed Toxoplasma encephalitis. 60 patient reports were analyzed: 22 patients (group 1) did not received didanosine in their antiretroviral treatment and 38 (group 2) were treated with didanosine. The results showed that an antiretroviral therapy was prescribed for 93 % of patients, 50 % of them received only zidovudine and protease inhibitors were prescribed for 37 %. The regimens given most frequently were those including zidovudine plus lamivudine or zidovudine plus indinavir. Among the group 1, 18 % have had a relapse of Toxoplasma encephalitis. In the group 2, 37 % of the patients suffered from one episode of TE while 16 % have had two TE after the pause in their didanosine treatment, the maximum occurring between 4 and 24 months after the pause of didanosine. This study showed that didanosine seems to have an effect on cerebral cysts. Also, this work made a synthesis about the different treatment used in AIDS patients and the new molecules yet in development against T. gondii.
Export Options
About this article
Cite this article as:
Sarciron Marie-Elisabeth, Gherardi Arnaud, Delorme Chantal, Peyramond Dominique and Petavy Anne-Francoise, Prevalence of Toxoplasma Encephalitis in AIDS Patients Treated with Didanosine Hospitalised in a French Infectious Service, Current HIV Research 2004; 2 (4) . https://dx.doi.org/10.2174/1570162043351101
DOI https://dx.doi.org/10.2174/1570162043351101 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Morphology of Atherosclerotic Plaque: Its Feature by Imaging Study
Current Pharmaceutical Design Antimicrobial and Structural Properties of Metal Ions Complexes with Thiosemicarbazide Motif and Related Heterocyclic Compounds
Current Medicinal Chemistry Targeting Cytokines, Chemokines and Adhesion Molecules in Rheumatoid Arthritis
Current Rheumatology Reviews Antimicrobial Sulfated Glycans: Structure and Function
Current Topics in Medicinal Chemistry Down with the Erythropoietin. Long Live the Erythropoietin !
Current Drug Targets How Computational Studies of Mosquito Repellents Contribute to the Control of Vector Borne Diseases
Current Computer-Aided Drug Design Current Clinical Applications of In Vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging
Current Medical Imaging Melatonin in Bacterial and Viral Infections with Focus on Sepsis: A Review
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery PFGE: Importance in Food Quality
Recent Patents on Food, Nutrition & Agriculture Astrocyte Infection by HIV-1: Mechanisms of Restricted Virus Replication, and Role in the Pathogenesis of HIV-1-Associated Dementia
Current HIV Research Genomic Databases and the Search of Protein Targets for Protozoan Parasites
Current Drug Targets The FDG-PET Revolution of Medical Imaging – Four Decades and Beyond
Current Molecular Imaging (Discontinued) Altering the Tropism of Lentiviral Vectors through Pseudotyping
Current Gene Therapy Cyclooxygenase and Neuroinflammation in Parkinsons Disease Neurodegeneration
Current Neuropharmacology Understanding Respiratory Syncytial Virus Infection to Improve Treatment and Immunity
Current Molecular Medicine Porphyrin Photosensitised Processes in the Prevention and Treatment of Water- and Vector-Borne Diseases
Current Medicinal Chemistry HIV-1 Capsid Inhibitors as Antiretroviral Agents
Current HIV Research Current Perspective of COVID-19 on Neurology: A Mechanistic Insight
Combinatorial Chemistry & High Throughput Screening Combinatorial Approaches to Iminosugars as Glycosidase and Glycosyltransferase Inhibitors
Combinatorial Chemistry & High Throughput Screening CD8+ T-cells: Are They Sufficient to Prevent, Contain or Eradicate HIV-1 Infection?
Current Drug Targets - Infectious Disorders