Abstract
Since its recognition as an endothelium-derived relaxing factor, the control and consequences of nitric oxide (NO) production has been investigated intensely. NO is not simply a vasodilator or regulator of smooth muscle tone but is a potent anti-platelet agent, neuromodulator and regulator of gene expression. This article reviews the mechanisms (intracellular Ca2+, phosphorylation and protein-protein interaction) that regulate the activity of each of the NO synthase isoforms and describes the physiology of NO in the circulation, kidney, skeletal muscle as well as in endocrine, immune and nervous systems.
Keywords: blood pressure, gene expression, phosphorylation, platelets, protein-protein association, reactive oxygen species, signal transduction, vascular tone
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
Title: The Physiology of Nitric Oxide: Control and Consequences
Volume: 3 Issue: 3
Author(s): Ingrid Fleming and Rudi Busse
Affiliation:
- Institut fur KardiovaskulärePhysiologie, Klinikum der J.W.G.-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany,Germany
Keywords: blood pressure, gene expression, phosphorylation, platelets, protein-protein association, reactive oxygen species, signal transduction, vascular tone
Abstract: Since its recognition as an endothelium-derived relaxing factor, the control and consequences of nitric oxide (NO) production has been investigated intensely. NO is not simply a vasodilator or regulator of smooth muscle tone but is a potent anti-platelet agent, neuromodulator and regulator of gene expression. This article reviews the mechanisms (intracellular Ca2+, phosphorylation and protein-protein interaction) that regulate the activity of each of the NO synthase isoforms and describes the physiology of NO in the circulation, kidney, skeletal muscle as well as in endocrine, immune and nervous systems.
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Cite this article as:
Fleming Ingrid and Busse Rudi, The Physiology of Nitric Oxide: Control and Consequences, Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents 2004; 3(3) . https://dx.doi.org/10.2174/1568014043355366
DOI https://dx.doi.org/10.2174/1568014043355366 |
Print ISSN 1568-0142 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6131 |
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