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Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Editor-in-Chief

ISSN (Print): 1568-0169
ISSN (Online): 1875-6174

L-Arginine Transport in Disease

Author(s): Antonio Claudio Mendes Ribeiro and Tatiana M. C. Brunini

Volume 2 , Issue 2 , 2004

Page: [123 - 131] Pages: 9

DOI: 10.2174/1568016043477288

Price: $65

Abstract

The importance of membrane transport in normal physiological cell function is unquestionable. However, to what extent alterations in the transport of amino acids are the cause and / or consequence of pathological changes observed in disease states is a question not yet completely clarified. Kinetic experiments with blood cells provide a simple and useful model for researching alterations in amino acid transport. The cationic amino acid L-arginine is the precursor of nitric oxide (NO), a key second messenger involved in functions such as endothelium-dependent vascular relaxation, immune defence and platelet activation. The transport of L-arginine, being rate-limiting for nitric oxide production, is extremely relevant to pathological conditions where NO synthesis and / or actions are affected. The current review provides an overview of L-arginine transport in disease, specifically in uraemia, heart failure, hypertension, diabetes mellitus, septic shock and sickle cell disease.

Keywords: l-arginine, nitric oxide, heart failure, uraemia, hypertension, sepsis, diabetes mellitus, sickle cell disease


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