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Current Drug Targets - Immune, Endocrine & Metabolic Disorders


ISSN (Print): 1568-0088
ISSN (Online): 1875-5917

The Sodium-Iodide Symporter

Author(s): C. H. Baker and J. C. Morris

Volume 4, Issue 3, 2004

Page: [167 - 174] Pages: 8

DOI: 10.2174/1568005310404030167

Price: $65


The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in nonthyroidal cancers through gene transfer for both diagnosis and treatment.

Keywords: sodium-iodide symporter, gene therapy, thyroid neoplasms

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