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Current Drug Targets - Inflammation & Allergy


ISSN (Print): 1568-010X
ISSN (Online): 1568-010X

Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis

Author(s): Bernhard Homey

Volume 3, Issue 2, 2004

Page: [169 - 174] Pages: 6

DOI: 10.2174/1568010043343840

Price: $65


Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.

Keywords: chemokines, chemokine receptors, psoriasis, therapy, ccr4, ccr6, cccr10, cxcr3

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