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Medicinal Chemistry Reviews - Online (Discontinued)


ISSN (Print): 1567-2034
ISSN (Online): 1567-2034

Chemotherapeutic Effects of Acridine Derivatives

Author(s): William A. Denny

Volume 1, Issue 3, 2004

Page: [257 - 266] Pages: 10

DOI: 10.2174/1567203043401923

Price: $65


Acridine derivatives show a broad range of biological activities. They have primarily been explored as chemotherapeutic agents (anticancer, antibacterial, antiprotozoal), because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase and telomerase enzymes. Research continues to be focussed primarily in these areas, but recent work shows they are active also as anticholinesterase agents.

Keywords: acridine, antibacterial, anticancer, antiprotozoal, anticholinesterase, telomerase

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