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Current Drug Targets - Immune, Endocrine & Metabolic Disorders


ISSN (Print): 1568-0088
ISSN (Online): 1875-5917

The New Immunosuppression: Intervention at the Dendritic Cell-T-Cell Interface

Author(s): A. M. Paterson, S. F. Yates, K. F. Nolan and H. Waldmann

Volume 5 , Issue 4 , 2005

Page: [397 - 411] Pages: 15

DOI: 10.2174/1568005310505040397

Price: $65


Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a tolerogenic context. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.

Keywords: Dendritic cells, T cells, immunological synapse, antibodies, pharmacological agents, tolerance

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