Classical antipsoriatic treatments reduce T-cell subsets, inhibit epidermal proliferation and affect keratinisation. These changes either can be primary or secondary to the resolution of the psoriatic lesion during treatments. During the last decade various studies described the effect of classical and innovative treatments on the various aspects of the psoriatic lesion. The aim of the present review is a critical evaluation of studies describing the response to psoriatic treatment at T-cells, NK-T cells and epidermal growth and differentiation. In particular the questions will be answered whether the profile of changes is treatment specific and which changes can be considered as early or late therapeutic effects.