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Current Drug Therapy


ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

In Vivo Effects of Topical Anti-Psoriatic Treatments on Cutaneous Inflammation, Epidermal Proliferation and Keratinisation

Author(s): Peter C.M. van de Kerkhof, H. Jorn Bovenschen and John E.M. Korver

Volume 2, Issue 1, 2007

Page: [21 - 26] Pages: 6

DOI: 10.2174/157488507779422428

Price: $65


Classical antipsoriatic treatments reduce T-cell subsets, inhibit epidermal proliferation and affect keratinisation. These changes either can be primary or secondary to the resolution of the psoriatic lesion during treatments. During the last decade various studies described the effect of classical and innovative treatments on the various aspects of the psoriatic lesion. The aim of the present review is a critical evaluation of studies describing the response to psoriatic treatment at T-cells, NK-T cells and epidermal growth and differentiation. In particular the questions will be answered whether the profile of changes is treatment specific and which changes can be considered as early or late therapeutic effects.

Keywords: T-cell activation, transit amplifying cells (TAC), Lesional Skin, calcipotriol, neutrophils

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