Abstract
The main focus of this report is the MR spectroscopy of the changes in the concentration of fluorine labeled photosensitizer that occur following the IP administration. This process is studied by 19F in vivo MR methodology in a murine tumor model. The animal model used in these studies was mice bearing radiation induced fibrosarcoma (RIF) tumor on the foot dorsum. The mice were injected with a solution of ∼ 100 micro-moles of the fluorinated photosensitizer and the 19F MR examination of the photosensitizer in the tumor or the muscle was performed. The pharmacokinetic (PK) profile for each labeled compound was generated using the 19F MR data at various time points post photosensitizer administration. The pharmacokinetic parameters were analyzed and the relationship of these results to photodynamic therapy is discussed. 19F MR methods clearly demonstrate utility in measuring the pharmacokinetic profiles and provide a new approach in the evaluation of appropriate photosensitizers for use in preclinical mammalian systems.
Keywords: 19F MR, RIF tumor, pharmacokinetics, fluorine labeled photosensitizers, photodynamic therapy (PDT), photofrin
Current Drug Discovery Technologies
Title: In vivo 19F MR Studies of Fluorine Labeled Photosensitizers in a Murine Tumor Model
Volume: 4 Issue: 2
Author(s): Subbaraya Ramaprasad, Elzbieta Ripp, Joseph Missert and Ravindra K. Pandey
Affiliation:
Keywords: 19F MR, RIF tumor, pharmacokinetics, fluorine labeled photosensitizers, photodynamic therapy (PDT), photofrin
Abstract: The main focus of this report is the MR spectroscopy of the changes in the concentration of fluorine labeled photosensitizer that occur following the IP administration. This process is studied by 19F in vivo MR methodology in a murine tumor model. The animal model used in these studies was mice bearing radiation induced fibrosarcoma (RIF) tumor on the foot dorsum. The mice were injected with a solution of ∼ 100 micro-moles of the fluorinated photosensitizer and the 19F MR examination of the photosensitizer in the tumor or the muscle was performed. The pharmacokinetic (PK) profile for each labeled compound was generated using the 19F MR data at various time points post photosensitizer administration. The pharmacokinetic parameters were analyzed and the relationship of these results to photodynamic therapy is discussed. 19F MR methods clearly demonstrate utility in measuring the pharmacokinetic profiles and provide a new approach in the evaluation of appropriate photosensitizers for use in preclinical mammalian systems.
Export Options
About this article
Cite this article as:
Subbaraya Ramaprasad , Elzbieta Ripp , Joseph Missert and Ravindra K. Pandey , In vivo 19F MR Studies of Fluorine Labeled Photosensitizers in a Murine Tumor Model, Current Drug Discovery Technologies 2007; 4 (2) . https://dx.doi.org/10.2174/157016307781483423
DOI https://dx.doi.org/10.2174/157016307781483423 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Effects of Newer Beta-Adrenoceptor Antagonists on Vascular Function in Cardiovascular Disease
Current Vascular Pharmacology Src Family Kinases: Potential Targets for the Treatment of Human Cancer and Leukemia
Current Pharmaceutical Design Adverse Effects of Statins - Mechanisms and Consequences
Current Drug Safety Chemically Modified Gelatin as Biomaterial in the Design of New Nanomedicines
Medicinal Chemistry Alternative Methods in Eradicating Helicobacter Pylori Infection
Current Pharmaceutical Analysis Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women
Current HIV Research Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives
Letters in Drug Design & Discovery CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297
Current Molecular Pharmacology Drug-Delivery Systems of Green Tea Catechins for Improved Stability and Bioavailability
Current Medicinal Chemistry The Role of Stress Proteins in Prostate Cancer
Current Genomics Virotherapy as An Approach Against Cancer Stem Cells
Current Gene Therapy Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines
Current Pharmaceutical Design Separation of Bioactive Peptides by Membrane Processes: Technologies and Devices
Recent Patents on Biotechnology Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models
Current Molecular Medicine Targeting Intestinal Transporters for Optimizing Oral Drug Absorption
Current Drug Metabolism Oleamide Derivatives are Prototypical Anti-Metastasis Drugs that Act by Inhibiting Connexin 26
Current Drug Safety Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3
Current Cancer Drug Targets Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain
Current Pharmaceutical Design Promises of Lipid-based Drug Delivery Systems in the Management of Breast Cancer
Current Pharmaceutical Design Recent Advances in Liposomal Drug Delivery: A Review
Pharmaceutical Nanotechnology