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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Application of In-Line Liquid Chromatography-Accurate Radioisotope Counting-Mass Spectrometry (LC-ARC-MS) to Evaluate Metabolic Profile of [3H]-Mefenamic Acid in Rat Plasma

Author(s): Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter and Abdul Mutlib

Volume 1, Issue 3, 2007

Page: [179 - 188] Pages: 10

DOI: 10.2174/187231207781369771

Price: $65


Profiling of rat plasma using a highly sensitive LC-ARC-MS technique showed that [3H] mefenamic acid was metabolized to several products, including a sulfate conjugate and a hydroxylated analogue as major metabolites. This technique of detecting low levels of radioactivity in plasma was superior to previously used methods, such as β-RAM detectors.

Keywords: Mefenamic acid metabolism, sulfate, glucuronide, LC-ARC-MS, plasma

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