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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Drug Interactions of Tipranavir, a New HIV Protease Inhibitor

Author(s): Judit Morello, Sonia Rodriguez-Novoa, Inmaculada Jimenez-Nacher and Vincent Soriano

Volume 1, Issue 1, 2007

Page: [81 - 84] Pages: 4

DOI: 10.2174/187231207779814256


Tipranavir is one of the latest approved HIV protease inhibitors. This non-peptidic molecule is an strong inducer of cytochrome P450 and has to be co-administered with low doses ritonavir as pharmacokinetic booster to achieve effective antiviral activity in vivo. As expected, significant drug interactions may occur in patients treated with tipranavir/ ritonavir, including diminished exposure to some antiretroviral agents. Although a few interactions can be managed with adequate drug dosing others preclude to use these medications in combination.

Keywords: Tipranavir, HIV, drug interactions, protease inhibitors

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