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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans

Author(s): Hai-Zhi Bu, William F. Pool, Ellen Y. Wu and Bhasker V. Shetty

Volume 1, Issue 1, 2007

Page: [61 - 65] Pages: 5

DOI: 10.2174/187231207779814373


Six tetra- and two penta-oxygenated capravirine metabolites observed in rats, dogs and humans represent the maximum numbers of isomers that can be predicted since oxygenations are restricted at the pyridinyl nitrogen (Noxidation), sulfur (sulfoxidation), and isopropyl group (hydroxylation), exemplifying a unique case that is very unusual for sequential drug metabolism.

Keywords: Capravirine, oxygenation, metabolism, structure elucidation, profiling, identification, biotransformation

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