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Drug Metabolism Letters


ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

Author(s): Akira Abe, Miki Hiraoka and James A. Shayman

Volume 1, Issue 1, 2007

Page: [49 - 53] Pages: 5

DOI: 10.2174/187231207779814292


Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.

Keywords: Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2

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