P2O5 Promoted One-Pot Synthesis of 3-aminoimidazo[1,2-a]pyridines under Solvent-Free Conditions

Title: P2O5 Promoted One-Pot Synthesis of 3-aminoimidazo[1,2-a]pyridines under Solvent-Free Conditions

Volume: 9 Issue: 3

Author(s): Ebrahim Soleimani, Mojtaba Taran, Mohsen Zainali and Shahram Lotfi

Affiliation:

Keywords: Imidazo[1,2-a]pyridine, P2O5, 2-Aminopyridine, Isocyanide, pyridines, pyrimidines, montmorillonite, benzaldehyde, aminopyridnes, pentoxide

Abstract: A facile, efficient and environment-friendly protocol for the synthesis of 3-aminoimidazo[1,2-a]pyridines has been developed by one-pot condensation of 2-aminopyridine, aromatic aldehyde and alkyl or aryl isocyanide in the presence of P2O5 as catalyst under solvent-free conditions at room temperature. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, high yield, easy purification, and economic availability of the catalyst.

Cite this article as:

Soleimani Ebrahim, Taran Mojtaba, Zainali Mohsen and Lotfi Shahram, P2O5 Promoted One-Pot Synthesis of 3-aminoimidazo[1,2-a]pyridines under Solvent-Free Conditions, Letters in Organic Chemistry 2012; 9 (3) . https://dx.doi.org/10.2174/157017812800167411