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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

BioArena Studies: Unique Function of Endogenous Formaldehyde and Ozone in the Antibiotic Effect – A Review

Author(s): Erno Tyihak, Agnes M. Moricz and Peter G. Ott

Volume 8, Issue 1, 2012

Page: [75 - 84] Pages: 10

DOI: 10.2174/157340612799278388

Price: $65


The investigations demonstrated clearly a unique function and role of endogenous formaldehyde (HCHO) and ozone (O3) in the antibiotic effect of diverse molecules having different chemical structure. Elimination of HCHO and/or O3 from the layer chromatographic spots resulted in a decrease in the antimicrobial activity. On the basis of detection and measure of endogenous HCHO and O3 BioArena enables to both direct isolation and biological evaluation of new bioactive compounds.

Keywords: Antibiotic, BioArena, cell proliferation, direct bioautography, formaldehyde, hydroxymethyl group, OPLC, ozone, troposphere, drug

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