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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Modulation of Signal-Transducing Function of Neuronal Membrane Na+,K by Endogenous Ouabain and Low-Power Infrared Radiation Leads to Pain Relief

Author(s): Ekaterina V. Lopatina, Igor L. Yachnev, Valentina A. Penniyaynen, Vera B. Plakhova, Svetlana A. Podzorova, Tatiana N. Shelykh, Ilya V. Rogachevsky, Irina P. Butkevich, Viktor A. Mikhailenko, Anna V. Kipenko and Boris V. Krylov

Volume 8, Issue 1, 2012

Page: [33 - 39] Pages: 7

DOI: 10.2174/157340612799278531

Price: $65


Effects of infrared (IR) radiation generated by a low-power Co2-laser on sensory neurons of chick embryos were investigated by organotypic culture method. Low-power IR radiation firstly results in marked neurite suppressing action, probably induced by activation of Na+,K+-ATPase signal-transducing function. A further increase in energy of radiation leads to stimulation of neurite growth. We suggest that this effect is triggered by activation of Na+,K+-ATPase pumping function. Involvement of Na+,K+-ATPase in the control of the transduction process was proved by results obtained after application of ouabain at very low concentrations. Physiological significance of low-power IR radiation and effects of ouabain at nanomolar level was investigated in behavioral experiments (formalin test). It is shown that inflammatory pain induced by injection of formalin is relieved both due to ouabain action and after IR irradiation.

Keywords: Na+,K+-ATPase, signal-transducing function, patch-clamp, organotypic tissue culture, formalin test, ouabain, infrared radiation, cardiac myocytes, smooth muscle cells, nerve tissue

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