Abstract
Effects of infrared (IR) radiation generated by a low-power Co2-laser on sensory neurons of chick embryos were investigated by organotypic culture method. Low-power IR radiation firstly results in marked neurite suppressing action, probably induced by activation of Na+,K+-ATPase signal-transducing function. A further increase in energy of radiation leads to stimulation of neurite growth. We suggest that this effect is triggered by activation of Na+,K+-ATPase pumping function. Involvement of Na+,K+-ATPase in the control of the transduction process was proved by results obtained after application of ouabain at very low concentrations. Physiological significance of low-power IR radiation and effects of ouabain at nanomolar level was investigated in behavioral experiments (formalin test). It is shown that inflammatory pain induced by injection of formalin is relieved both due to ouabain action and after IR irradiation.
Keywords: Na+,K+-ATPase, signal-transducing function, patch-clamp, organotypic tissue culture, formalin test, ouabain, infrared radiation, cardiac myocytes, smooth muscle cells, nerve tissue
Medicinal Chemistry
Title: Modulation of Signal-Transducing Function of Neuronal Membrane Na+,K by Endogenous Ouabain and Low-Power Infrared Radiation Leads to Pain Relief
Volume: 8 Issue: 1
Author(s): Ekaterina V. Lopatina, Igor L. Yachnev, Valentina A. Penniyaynen, Vera B. Plakhova, Svetlana A. Podzorova, Tatiana N. Shelykh, Ilya V. Rogachevsky, Irina P. Butkevich, Viktor A. Mikhailenko, Anna V. Kipenko and Boris V. Krylov
Affiliation:
Keywords: Na+,K+-ATPase, signal-transducing function, patch-clamp, organotypic tissue culture, formalin test, ouabain, infrared radiation, cardiac myocytes, smooth muscle cells, nerve tissue
Abstract: Effects of infrared (IR) radiation generated by a low-power Co2-laser on sensory neurons of chick embryos were investigated by organotypic culture method. Low-power IR radiation firstly results in marked neurite suppressing action, probably induced by activation of Na+,K+-ATPase signal-transducing function. A further increase in energy of radiation leads to stimulation of neurite growth. We suggest that this effect is triggered by activation of Na+,K+-ATPase pumping function. Involvement of Na+,K+-ATPase in the control of the transduction process was proved by results obtained after application of ouabain at very low concentrations. Physiological significance of low-power IR radiation and effects of ouabain at nanomolar level was investigated in behavioral experiments (formalin test). It is shown that inflammatory pain induced by injection of formalin is relieved both due to ouabain action and after IR irradiation.
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V. Lopatina Ekaterina, L. Yachnev Igor, A. Penniyaynen Valentina, B. Plakhova Vera, A. Podzorova Svetlana, N. Shelykh Tatiana, V. Rogachevsky Ilya, P. Butkevich Irina, A. Mikhailenko Viktor, V. Kipenko Anna and V. Krylov Boris, Modulation of Signal-Transducing Function of Neuronal Membrane Na+,K by Endogenous Ouabain and Low-Power Infrared Radiation Leads to Pain Relief, Medicinal Chemistry 2012; 8 (1) . https://dx.doi.org/10.2174/157340612799278531
DOI https://dx.doi.org/10.2174/157340612799278531 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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