One Pot Synthesis and In Vitro Antitumor Activity of some Bipyrazolic Tripodal Derivatives

Title: One Pot Synthesis and In Vitro Antitumor Activity of some Bipyrazolic Tripodal Derivatives

Volume: 9 Issue: 3

Author(s): Smaail Radi, Yahya Toubi, Nihed Draoui, Olivier Feron and Olivier Riant

Affiliation:

Keywords: Antitumor activity, Bipyrazoles, LoVo, MDA-MB231, PC3, Synthesis, Pyrazole derivatives, biologically active heterocyclic compounds, bipyrazole-3-carboxylates, Biological Assays, aniline ring, macrocyclic, MTT tests, DMSO, moiety, antitumor activity

Abstract: The synthesis and structure – activity relationships (SAR) antitumor activities of monopyrazolic and bipyrazolic tripodal derivatives are reported here for the first time. The ten products were tested against three human cancer cell lines including breast (MDA-MB231), prostate (PC3) and colorectal (LoVo) cancers. In bipyrazolic series, most of them exhibited a moderate antitumor activity against three human cancer cell lines with an order of 5 > 7 > 8 in case of colorectal cancer and 5 > 7 ≉ 8 in case of breast and prostate cancers.

Cite this article as:

Radi Smaail, Toubi Yahya, Draoui Nihed, Feron Olivier and Riant Olivier, One Pot Synthesis and In Vitro Antitumor Activity of some Bipyrazolic Tripodal Derivatives, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129792