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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions

Author(s): Said El Kazzouli, Sabine Berteina-Raboin, Abderrahim Mouaddib and Gerald Guillaumet

Volume 9, Issue 2, 2012

Page: [118 - 127] Pages: 10

DOI: 10.2174/157017812800221753

Price: $65


Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound α-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6- Position of polymer-bound imidazo[1,2-a]pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction

Keywords: Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine, microwave irradiations, solid phase synthesis, Suzuki-Miyaura cross-coupling, antiviral, antiulcer, antibacterial, antifungal, receptor ligands, calcium channel blocker

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