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Current Women`s Health Reviews


ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Hereditary Breast Cancer in Sub-Saharan Africa

Author(s): Khalid Dafaallah Awadelkarim, Ahmed Elhaj, Gitana Aceto, Renato Mariani-Costantini and Elgaylani Abdalla Eltayeb

Volume 8, Issue 1, 2012

Page: [44 - 54] Pages: 11

DOI: 10.2174/157340412799079219

Price: $65


Little is known about breast cancer in Sub-Saharan Africa, where the incidence of this neoplasm is estimated to be lower than in developed countries. Yet, as a result of several factors, among which demographic structures, lifestyle, reproductive, environmental and socio-economic factors, including traditional beliefs, and access to diagnostic facilities and medical care, the majority of the patients present with locally advanced and metastatic disease and early onset breast cancer is frequent in institutional cancer series. This review reports the current knowledge on hereditary breast cancer and early onset breast cancer in Sub-Saharan Africa as emerging from the available studies, with special emphasis on those conducted in Sudan.

Keywords: BRCA1, BRCA2, early onset, genetics, Hereditary breast cancer, pathology, Sub-Saharan Africa, breast cancer in Sudan, neoplasm, PALB2

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