Abstract
Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human cytochrome P450 SNPs (Single Nucleotide Polymorphisms) based on the SVM flanking sequence method; SCYPPred can rapidly yield the desired results by using the amino acid sequences information alone. The web-server is accessible to the public at http://snppred.sjtu.edu.cn. Hopefully SCYPPred could be a useful bioinformatics tool for elucidating the mutation probability of a specific CYP450 enzyme.
Keywords: Cytochrome P450, SNPs, SVM, Mutation Probability, Human cytochrome, SCYPPred, SVM flanking, hemoproteins, archaea, DNA-sequence, Vector encoding, KEGG, RBF, FN, Single Nucleotide Polymorphisms, benchmark dataset
Protein & Peptide Letters
Title: SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450
Volume: 19 Issue: 1
Author(s): Li Li, Dong-Qing Wei, Jing-Fang Wang and Kuo-Chen Chou
Affiliation:
Keywords: Cytochrome P450, SNPs, SVM, Mutation Probability, Human cytochrome, SCYPPred, SVM flanking, hemoproteins, archaea, DNA-sequence, Vector encoding, KEGG, RBF, FN, Single Nucleotide Polymorphisms, benchmark dataset
Abstract: Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human cytochrome P450 SNPs (Single Nucleotide Polymorphisms) based on the SVM flanking sequence method; SCYPPred can rapidly yield the desired results by using the amino acid sequences information alone. The web-server is accessible to the public at http://snppred.sjtu.edu.cn. Hopefully SCYPPred could be a useful bioinformatics tool for elucidating the mutation probability of a specific CYP450 enzyme.
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Cite this article as:
Li Li, Wei Dong-Qing, Wang Jing-Fang and Chou Kuo-Chen, SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450, Protein & Peptide Letters 2012; 19 (1) . https://dx.doi.org/10.2174/092986612798472785
DOI https://dx.doi.org/10.2174/092986612798472785 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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