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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Efficient Synthesis of Piperazinediones Using Potassium Iodide Catalysis in Aqueous Media

Author(s): Yong-Hong Wen, Xiao-Na Chen, Hui-Ling Wen and Xiao-Fang Tang

Volume 8, Issue 10, 2011

Page: [732 - 736] Pages: 5

DOI: 10.2174/157017811799304098

Price: $65


A simple and efficient synthetic approach to 1,4-disubstituted piperazine-2,5-diones was developed. A series of symmetrical 1,4-disubstituted piperazine-2,5-diones was prepared from chloroacetamides using potassium iodide catalysis in acetone/water. The structures of two products were confirmed by single crystal X-ray diffraction analysis.

Keywords: Chloroacetamide, cyclization reaction, diketopiperazine, piperazinedione, bradykinin, antagonists, agonists, chloroacetamides, acetamide, amino acids

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