Abstract
Tuberculosis is a major global health problem: the World Health Organisation estimates that there were 9.4 million incident cases and 1.8 million deaths from the disease in 2008. The development of new agents to prevent acquisition or reactivation of latent Mycobacterium tuberculosis infection and to allow shortening of antimicrobial therapy regimens for active tuberculosis without loss of efficacy is a research priority. In this article we describe the immunomodulatory actions of vitamin D metabolites in mycobacterial infection and review the growing body of evidence from observational and intervention studies suggesting that vitamin D might have a role in the prevention and treatment of TB.
Keywords: Tuberculosis, vitamin D, immunomodulation, clinical trials, Mycobacterium tuberculosis, Human Immunodeficiency Virus, macrophage, anti-tuberculous chemotherapy, vitamin D binding protein (DBP), polymorphism
Current Respiratory Medicine Reviews
Title: Vitamin D and Tuberculosis
Volume: 7 Issue: 6
Author(s): Kirsten Mitchell, Christopher J. Griffiths and Adrian R. Martineau
Affiliation:
Keywords: Tuberculosis, vitamin D, immunomodulation, clinical trials, Mycobacterium tuberculosis, Human Immunodeficiency Virus, macrophage, anti-tuberculous chemotherapy, vitamin D binding protein (DBP), polymorphism
Abstract: Tuberculosis is a major global health problem: the World Health Organisation estimates that there were 9.4 million incident cases and 1.8 million deaths from the disease in 2008. The development of new agents to prevent acquisition or reactivation of latent Mycobacterium tuberculosis infection and to allow shortening of antimicrobial therapy regimens for active tuberculosis without loss of efficacy is a research priority. In this article we describe the immunomodulatory actions of vitamin D metabolites in mycobacterial infection and review the growing body of evidence from observational and intervention studies suggesting that vitamin D might have a role in the prevention and treatment of TB.
Export Options
About this article
Cite this article as:
Mitchell Kirsten, J. Griffiths Christopher and R. Martineau Adrian, Vitamin D and Tuberculosis, Current Respiratory Medicine Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339811798072685
DOI https://dx.doi.org/10.2174/157339811798072685 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
Current Microwave Chemistry Artery of Percheron Infarction: A Characteristic Pattern of Ischemia and Variable Clinical Presentation: A Literature Review
Current Medical Imaging Protein Microarrays for Studies of Drug Mechanisms and Biomarker Discovery in the Era of Systems Biology
Current Pharmaceutical Design Pharmacological Targeting of the Inflamed Intestinal Barrier
Current Pharmaceutical Design Graphical Abstracts:
Letters in Drug Design & Discovery Tumor Necrosis Factor Inhibitors as Therapeutic Choice in Psoriasis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Recognition of Protein-coding Genes Based on Z-curve Algorithms
Current Genomics Patent Selections
Recent Patents on Drug Delivery & Formulation Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints
Current Drug Delivery Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector
Current HIV Research Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Medical and Societal Impact
Current Immunology Reviews (Discontinued) A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines
Current Medicinal Chemistry A Synopsis of Nano-Technological Approaches Toward Anti-Epilepsy Therapy: Present and Future Research Implications
Current Drug Metabolism Bilosomes: A Novel Approach to Meet the Challenges in Oral Immunization
Recent Patents on Drug Delivery & Formulation Tetraoxanes as Antimalarials: Harnessing the Endoperoxide
Mini-Reviews in Medicinal Chemistry Simulating the Interactions of Toxins with K+ Channels
Current Pharmaceutical Design Structure-based Discovery of Novel Antibacterials
Anti-Infective Agents in Medicinal Chemistry Pharmacokinetics and Pharmacokinetic Variability of Heroin and its Metabolites: Review of the Literature
Current Clinical Pharmacology Nasal Polyposis: An Overview of Differential Diagnosis and Treatment
Recent Patents on Inflammation & Allergy Drug Discovery Hypersensitivity Reactions to Quinolones
Current Pharmaceutical Design