Abstract
Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear ruthenium, osmium and gold complexes, focusing on their anticancer activity. The compounds presented are often supposed to exert their anticancer activity by different modes of action as compared to established drugs, including newly proposed mechanisms such as enzyme inhibition, crosslinking of biomacromolecules or through photo-activation, though many of the examples are also capable of binding to DNA nucleobases. Important metabolization and chemical characteristics of such compounds are discussed, and if the appropriate data is available, molecular modes of action are highlighted.
Keywords: Bioorganometallics, cancer chemotherapy, coordination compounds, mode of action, polynuclear complexes, metalloclusters, Polynuclear compounds, trinuclear Pt compound BBR3464, polynuclear ruthenium, osmium and gold complexes, enzyme inhibition, crosslinking, photo-activation, DNA nucleobases, modes of action, Osmium and Gold Complexes
Current Topics in Medicinal Chemistry
Title: Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics
Volume: 11 Issue: 21
Author(s): Christian G. Hartinger, Andrew D. Phillips and Alexey A. Nazarov
Affiliation:
Keywords: Bioorganometallics, cancer chemotherapy, coordination compounds, mode of action, polynuclear complexes, metalloclusters, Polynuclear compounds, trinuclear Pt compound BBR3464, polynuclear ruthenium, osmium and gold complexes, enzyme inhibition, crosslinking, photo-activation, DNA nucleobases, modes of action, Osmium and Gold Complexes
Abstract: Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear ruthenium, osmium and gold complexes, focusing on their anticancer activity. The compounds presented are often supposed to exert their anticancer activity by different modes of action as compared to established drugs, including newly proposed mechanisms such as enzyme inhibition, crosslinking of biomacromolecules or through photo-activation, though many of the examples are also capable of binding to DNA nucleobases. Important metabolization and chemical characteristics of such compounds are discussed, and if the appropriate data is available, molecular modes of action are highlighted.
Export Options
About this article
Cite this article as:
G. Hartinger Christian, D. Phillips Andrew and A. Nazarov Alexey, Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics, Current Topics in Medicinal Chemistry 2011; 11(21) . https://dx.doi.org/10.2174/156802611798040769
DOI https://dx.doi.org/10.2174/156802611798040769 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |

- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility Of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
- Forthcoming Thematic Issues
Related Articles
-
Dendritic Cells in Colorectal Cancer and a Potential for their Use in Therapeutic Approaches
Current Pharmaceutical Design Synthetic Nanocarriers for Intracellular Protein Delivery
Current Drug Metabolism Modulation of Photosensitization Processes for an Improved Targeted Photodynamic Therapy
Current Medicinal Chemistry Gene Directed Enzyme Prodrug Therapy for Ovarian Cancer: Could GDEPT Become a Promising Treatment Against Ovarian Cancer?
Anti-Cancer Agents in Medicinal Chemistry Evaluation of High Risk HPV (HPV-16 and -18) RNA and Integration in Cervical Neoplasms in Systemic Lupus Erythematosus
Current Women`s Health Reviews HPV Screening: Available Data and Recommendations for Clinical Practice
Current Cancer Therapy Reviews The Molecular Basis of Notch Signaling Regulation: A Complex Simplicity
Current Molecular Medicine Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
Current Pharmaceutical Design Purinergic Signalling: What is Missing and Needed Next? The Use of Transgenic Mice, Crystallographic Analysis and MicroRNA
CNS & Neurological Disorders - Drug Targets Chalcones as Promising Lead Compounds on Cancer Therapy
Current Medicinal Chemistry Protein-Based HIV-1 Microbicides
Current HIV Research An Update on the Other Telomerase Inhibitors: Non-G-Quadruplex Interactive Agent, Non-Antisense, Non-Reverse Transcriptase Telomerase Inhibitors
Medicinal Chemistry Reviews - Online (Discontinued) The Role of Phenolic Compounds in the Fight against Cancer – A Review
Anti-Cancer Agents in Medicinal Chemistry Gold Coordination Complexes as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Non-histone Methylation of SET7/9 and its Biological Functions
Recent Patents on Anti-Cancer Drug Discovery Current Constructs and Targets in Clinical Development for Antibody- Based Cancer Therapy
Current Drug Targets Editorial (Thematic Issue: Epigenetic Regulation and Human Diseases)
Current Pharmaceutical Design Thiourea and Guanidine Derivatives as Antimalarial and Antimicrobial Agents<sup>§</sup>
Current Topics in Medicinal Chemistry Analgesic and Anti-Inflammatory Properties of Arylnitroalkenes
Inflammation & Allergy - Drug Targets (Discontinued) Signal Transduction and Heavy Ion Radiation Therapy: Biological Mechanisms, Biological Quality Assurance, and New Multimodality Approach
Current Signal Transduction Therapy