Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4Hpyrido[ 1,2-a]pyrimidin-4-one Derivatives as Antimicrobial Agents

Title: Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4Hpyrido[ 1,2-a]pyrimidin-4-one Derivatives as Antimicrobial Agents

Volume: 8 Issue: 10

Author(s): Byregowda Krishnamurthy, Kambappa Vinaya, Doddakunche S. Prasanna, Byregowda Raghava and Kanchugarakoppal S. Rangappa

Affiliation:

Keywords: Acid chlorides, Antimicrobial activity, 2-Aminopyridine, Phosphorous oxychloride, Piperazine, Sulfonyl chlorides, carboxamide, sulfonamide, H-NMR, FTIR, Staphylococcus epidermidis, Pseudomonas aeruginosa, MTCC, Antimicrobial, antitubercular, beta-lactam derivatives

Abstract: A series of novel 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one sulfonamide and carboxamide derivatives were synthesized in good yield. The synthesized compounds were characterized by 1H-NMR, FTIR and elemental analysis. All the synthesised compounds were screened for their in vitro antimicrobial activity by agar well diffusion and micro dilution method against standard strains of Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus epidermidis 435), and Gram-negative (Xanthomonas campestris 7903 and Pseudomonas aeruginosa MTCC 7908) bacteria. Compound 7a and compound 8d with dichloro substitution among sulphonamide and carboxamide series respectively showed potent inhibitory activity.

Cite this article as:

Krishnamurthy Byregowda, Vinaya Kambappa, S. Prasanna Doddakunche, Raghava Byregowda and S. Rangappa Kanchugarakoppal, Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4Hpyrido[ 1,2-a]pyrimidin-4-one Derivatives as Antimicrobial Agents, Letters in Drug Design & Discovery 2011; 8(10) . https://dx.doi.org/10.2174/157018011797655304