Generic placeholder image

Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents

Author(s): Z. Li, P. Zhan and X. Liu

Volume 11, Issue 13, 2011

Page: [1130 - 1142] Pages: 13

DOI: 10.2174/138955711797655407

Price: $65


1,3,4-oxadiazole, a privileged structure, endows its derivatives with broad and potent biological functions, especially in antiviral activities, including anti-HIV, anti-HCV, anti-HBV, anti-HSV activities, etc. Molecular modeling and pharmacokinetic studies have demonstrated that the introduction of 1,3,4-oxadiazole ring to the inhibitors can change their polarity, flexibility as well as metabolic stability, and 1,3,4-oxadiazole scaffold can also act as acceptors of hydrogen bonds formation, which make it possible to be used as a isosteric substituent for amide or ester groups.

This review focuses on the recent advances in the synthesis of 1,3,4-oxadiazole ring and mainly the discovery, biological activities investigations and structural modifications of several distinct classes of 1,3,4-oxadiazoles as potent antiviral agents. In addition, the binding models of some representative 1,3,4-oxadiazoles were also discussed, which provide rational explanation for their interesting antiviral activities, and also pave the way for further optimization of 1,3,4- oxadiazole based antiviral agents.

Keywords: 1, 3, 4-Oxadiazole, privileged structure, solid-phase synthesis, antiviral activity, structural modification, molecule modeling, scaffold, Microwave-Assisted, NNRTIs, alkenyldiarylmethanes, Protease Inhibitors, Integrase Inhibitors

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy