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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Reciprocal Interactions Between Wakefulness and Sleep Influence Global and Regional Brain Activity

Author(s): Vincenzo Muto, Laura Mascetti, Luca Matarazzo, Caroline Kusse, Ariane Foret, Anahita Shaffii-Le Bourdiec, Gilles Vandewalle, Derk Jan Dijk and Pierre Maquet

Volume 11 , Issue 19 , 2011

Page: [2403 - 2413] Pages: 11

DOI: 10.2174/156802611797470358

Price: $65


Reciprocal interactions between wakefulness and sleep substantially influence human brain function in both states of vigilance. On the one hand, there is evidence that regionally-specialized brain activity during wakefulness is modulated by the interaction between a local use-dependent buildup of homeostatic sleep pressure and circadian signals. On the other hand, brain activity during sleep, although mainly constrained by genuine sleep oscillations, shows wakedependent regionally-specific modulations, which are involved in the dissipation of local homeostatic sleep pressure and memory consolidation.

Keywords: Sleep, slow waves, spindles, REM sleep, circadian rhythms, cognition, memory, neuroimaging, circadian signals, memory consolidation, regional modifications of brain, homeostatic regulation, core components, posterior cingulate cortices

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