Abstract
The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.
Keywords: 16-membered macrolides, structural flexibility, mycarose moiety, antimicrobial properties, resistant strains, resistance mechanism, tylosin, leucomycin, bacterial resistance, gastrointestinal
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Field of 16-Membered Macrolide Antibiotics
Volume: 11 Issue: 12
Author(s): W. Cui and S. Ma
Affiliation:
Keywords: 16-membered macrolides, structural flexibility, mycarose moiety, antimicrobial properties, resistant strains, resistance mechanism, tylosin, leucomycin, bacterial resistance, gastrointestinal
Abstract: The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.
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Cite this article as:
Cui W. and Ma S., Recent Advances in the Field of 16-Membered Macrolide Antibiotics, Mini-Reviews in Medicinal Chemistry 2011; 11 (12) . https://dx.doi.org/10.2174/138955711797247734
DOI https://dx.doi.org/10.2174/138955711797247734 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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