Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Cytotoxicity Study on Some Synthetic Aromatic Esters of 4-Demethyl-4-deoxypodophyllotoxin

Author(s): Juan-Juan Wang, Hong-Jin Han, Guang-Zhi Zeng, Hui Xu and Ning-Hua Tan

Volume 8, Issue 9, 2011

Page: [857 - 860] Pages: 4

DOI: 10.2174/157018011797200849

Price: $65


To search for potential anti-cancer analogs, 16 aromatic esters of 4-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.

Keywords: Aromatic ester, Cytotoxicity, Deoxypodophyllotoxin, Aromatic Esters, Podophyllotoxin, antiproliferative, antitumor, carboxylalkyl, MS, 1H NMR, HRMS, Reed-Muench method

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy