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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis

Author(s): Shun-Ichiro Ogura, Yuichiro Hagiya, Kenji Tabata, Toshiaki Kamachi and Ichiro Okura

Volume 12, Issue 3, 2012

Page: [176 - 184] Pages: 9

DOI: 10.2174/156802612799078883

Price: $65


Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.

Keywords: Photodynamic therapy, phthalocyanine, aminolevulinic acid, immunoconjugate, photodynamic diagnosis, tumor marker, porphyrin 5-aminolevulinic acid, ophthalmic tumors, fluorescence diagnosis, target tissues, photosensitizer, hematoporphyrin derivative, tumor tissue occurs, hemoglobin, photodynamic treatment

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