Generic placeholder image

Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Rapid and Efficient Synthesis of New Deoxycholic Acid Thiosemicarbazone Derivatives under Solvent-Free Conditions using Microwaves

Author(s): Zhi-Chuan Shi, Zhi-Gang Zhao, Xing-Li Liu and Li-Ying Qiu

Volume 8, Issue 7, 2011

Page: [515 - 519] Pages: 5

DOI: 10.2174/157017811796505016

Price: $65


An efficient and simple method for the synthesis of new deoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave irradiation has been developed. Its main advantages are short reaction times, good conversions, highly selective and the environment friendly nature of the process. Their structures were elucidated by IR, 1H NMR, ESI-Mass and elemental analyses. The preliminary results indicate that some of these compounds possess inhibitory effects against Escherichia coli.

Keywords: Antimicrobial activity, deoxycholic acid, microwave irradiation, solvent-free, steroids, thiosemicarbazone, ESI-Mass, elemental analyses, deoxycholic, antimalarial agents

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy