Solid-Phase Synthesis of Di-N-Acetyl-β-Chitobiosyl Allosamizoline

Title: Solid-Phase Synthesis of Di-N-Acetyl-β-Chitobiosyl Allosamizoline

Volume: 8 Issue: 9

Author(s): Gangliang Huang

Affiliation:

Keywords: Allosamidin analogue, di-N-acetyl-β-chitobiosyl allosamizoline, glycosylation reactions, solid-phase synthesis, trichloroacetimidate donors, wang resin, antifungal agents, Acetylation, Regioselective, diisopropylcarbodiimide

Abstract: The solid-phase synthesis of di-N-acetyl-β-chitobiosyl allosamizoline 2 was reported. After the 6-O-benzyl allosamizoline 16, NHCbz trichloroacetimidate donors 7, and 14 were synthesized; solid-phase synthesis was performed using the Wang resin as support. The target di-N-acetyl-β-chitobiosyl allosamizoline 2 was obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively.

Cite this article as:

Huang Gangliang, Solid-Phase Synthesis of Di-N-Acetyl-β-Chitobiosyl Allosamizoline, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304331