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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Molecular Imaging Probe Development Using Microfluidics

Author(s): Kan Liu, Ming-Wei Wang, Wei-Yu Lin, Duy Linh Phung, Mark D. Girgis, Anna M. Wu, James S. Tomlinson and Clifton K.-F. Shen

Volume 8 , Issue 4 , 2011

Page: [473 - 487] Pages: 15

DOI: 10.2174/157017911796117205

Price: $65

Abstract

In this manuscript, we review the latest advancement of microfluidics in molecular imaging probe development. Due to increasing needs for medical imaging, high demand for many types of molecular imaging probes will have to be met by exploiting novel chemistry/radiochemistry and engineering technologies to improve the production and development of suitable probes. The microfluidicbased probe synthesis is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional systems. Numerous chemical reactions have been successfully performed in micro-reactors and the results convincingly demonstrate with great benefits to aid synthetic procedures, such as purer products, higher yields, shorter reaction times compared to the corresponding batch/macroscale reactions, and more benign reaction conditions. Several ‘proof-of-principle’ examples of molecular imaging probe syntheses using microfluidics, along with basics of device architecture and operation, and their potential limitations are discussed here.

Keywords: Microfluidics, molecular imaging, Probe Developments, Magnetic Resonance Imaging, Quantum Dots, Ultrasound Imaging, Microfluidic Devices, Imaging Modalities, Fluorescent Tags for Optical Imaging, Positron Emission Tomography


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